Toxigenic strains of Escherichia coli are common enteric The present study was conducted to detect common pathogens of urinary tract infection (UTI) and their susceptibility pattern to the commonly used antimicrobial agents in local scenario. Urinary tract infection is one of the common clinical conditions in the patients presenting to the clinics and hospitals. Despite the widespread availability of antibiotics, it remains the most common bacterial infection in the human being. Detection of common pathogens and their antimicrobial susceptibility pattern is mandatory for effective treatment. In the present study, 40 urine samples were collected from adult patients were analyzed for Multidrug Resistant (MDR) strain isolation and identified. The MDR strains were identified by the Kirby Bauer method following the definition of the National Committee of Clinical Laboratory Standards. Out of total 40 samples, 32 (80%) samples grew potential pathogens causing UTI. Escherichia coli were the predominant 10 (31.25%) isolates causing UTI, followed by Staphylococcus aureus -8 (25%), Pseudomonas aeruginosa- 5 (15.62%), Proteus mirabilis -5 (15.62%), Klebsiella pneumoniae -2 (6.25%) and Serratia marcescens – 2 (6.25%). The mean sensitivity of the antibiotics was Tetracyclin (76.66%), Penicillin (70.83%), Ciprofloxacin (60%). S. aureus showed 75% resistance to Methicillin, Oxacillin and Vancomycin. Uropathogens are sensitive to Norfloxacin, Co-trimoxazole and Ofloxacin. High prevalence of drug-resistant urinary tract pathogens, particularly to Tetracylin, Penicillin and Ampicillin among local patients suggests cautious use of antibiotic therapy for the treatment. Finally, we suggest that empirical antibiotic selection should be based on knowledge of the local prevalence of bacterial organisms and antibiotic sensitivities rather than on universal guidelines.