Asian Journal of Biomedical and Pharmaceutical Sciences

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Preparation and evaluation of microparticles containing Oxybutynin Chloride for controlled release

In the present research, an attempt has been made to prepare microparticles of Oxybutynin chloride. Particulate technologies have often proven popular among the oral controlled drug delivery technologies because of their simplicity, easy in manufacturing, high level of reproducibility and easy of scale up and process validation. Oxybutynin chloride is antimuscarinic and antispasmodic drug used for the treatment of urine incontinence in women. Different formulations were prepared by solvent evaporation method by using different ratios of drug and polymer (HPMC K45M, Ethyl Cellulose). The prepared microparticles were evaluated for drug polymer compatibility, the results shown that there were no significant interactions. The encapsulation efficacy was ranging from 56-96%. The in-vitro drug release studies indicate the release of drug in a controlled manner over a period of 12 hrs. It was found that the Oxybutynin release rate increased with a decreased amount of polymer. This can be adjusted by maintaining the concentration of the polymers.

Author(s): Nagendra R, Charan CS, K. Hanumanthachar Joshi, Jayanthi C