Asian Journal of Biomedical and Pharmaceutical Sciences

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Papain Catalyzed: Multicomponent Synthesis of Trisubstituted Imidazoles

A reliable synthetic method has been developed for 2, 4, 5-trisubstituted imidazole from benzil, ammonium acetate, and aromatic aldehyde by using papain a non toxic and inexpensive catalyst. The Structural features have been arrived at from their analytical data, IR, Mass, 1H NMR. The antibacterial activity of all synthesized compound has been performed by using filter paper disc method against gram positive and gram negative bacteria.We observed that 4a –compound is more active against gram +ve S. Typhi at lower concentration 4f less active against gram +ve S. Typhi and gram –ve E. Coli

Author(s): P.V.Maske, S. J. Makhija