Medicinal plants have played a very important role in the rejuvenation of worse situation created by the infection of microorganisms. In addition, many new structures of Antibiotic agents are developed using medicinal plants as the resource. Plants are oldest source of pharmacologically active compounds. In the field of Ethnopharmacology, the search for new anti-infection agents has occupied many research groups in the past few decades. According to estimation more than two thirds of the world’s population relays on plant derived drugs. There are no of plant products like garlic, Aloe Vera, Croton Latex, Eucalyptus Essential Oil, Grapefruit seed extract (GSE), Usnea and etc., used as a natural antibiotics in the treatment of burns, respiratory tract infections, stimulates immune system, lowers blood pressure, severe diarrhea and etc.