Asian Journal of Biomedical and Pharmaceutical Sciences

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Modeling Ventricular Muscle Cell by the Least Parameters

Modeling the dynamics of ventricular muscle cell require models that reproduce realistic characteristics in cell. In this paper, we present a minimal model for ventricular muscle cell that is designed to reproduce important characteristics of cardiac cell, including action potential (AP) amplitudes and morphologies, excitability and all or none criteria. To generate the minimal model, first, we presented a general form of a nonlinear model with twostate variables for the cell, and then parameters of the model have been fitted by using the theories and experiments that has done on COR software. Findings show the proposed minimal model has important features for example; it is simple and is computationally efficient.

Author(s): S. Esmaeili, S. H. Sabzposhan