Asian Journal of Biomedical and Pharmaceutical Sciences

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Media Optimization Studies for Enhanced Production of Serratiopeptidase from Bacillus Licheniformis (NCIM 2042)

Production of an anti inflammatory Serratiopeptidase by fermentation with Serratia marcescens NCIM 2919 was studied to ascertain optimal nutritional conditions for large scale production. To study biosynthesis and production of Serratiopeptidase by isolated Bacillus Licheniformis (NCIM 2042) different growth media were studied. The modified fermentation medium concentration of Serratiopeptidase was found to be 22.85 IU/ml at temperature 35 °C, pH 6.5 after 24 hours duration. Before optimization of fermentation medium concentration of Serratiopeptidase was found 16.52 IU/ml at temperature 30 °C and pH 7.0 after 48 hours duration.

Author(s): Manasi J. Wagdarikar, Anagha M. Joshi, Amir A. Shaikh