Asian Journal of Biomedical and Pharmaceutical Sciences

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Literature review on Biodegradable Nanospheres for Oral and Targeted Drug Delivery

Nanosphere systems have great potentials, being able to convert poorly soluble, poorly absorbed and labile biologically active substance into promising deliverable drugs. The core of this system can enclose a variety of drugs, enzymes, genes and is characterized by a long circulation time due to the hydrophilic shell which prevents recognition by the reticular-endothelial system. To optimize this drug delivery system, greater understanding of the different mechanisms of biological interactions, and particle engineering, is still required. Further advances are needed in order to turn the concept of nanoparticles technology into a realistic practical application as the next generation of drug delivery system.

Author(s): Bethelhem Mamo, Mesin kedir, Workneh Abebe, Tesfaye D Gabriel