Nephrotic syndrome is a set of indications that include protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. Nephrotic syndrome is affected by changed disorders that damage the kidneys. This impairment leads to the release of too much protein in the urine. Hyperlipidemia is a common finding in nephrotic syndrome. There is increased total Cholesterol, LDL, VLDL and low or normal HDL. It has been noted that certain factors like diet, malnutrition, genetic traits etc., are known to alter the frequency and severity of lipid pattern. The Indian patient has a different dietary, constitutional and genetic background. An attempt was also made to correlate the degree of proteinuria and hypoproteinemia, with the rise in serum lipid values in cases of nephrotic syndrome. This is a Cross sectional study in which 30 Normal patients and 30 patients with nephrotic syndrome aged 25-65 years old. The Serum Protein & Serum lipid profiles of the admitted patients were evaluated. There was a significant increase in Total cholesterol, HDL, LDL, VLDC & TG. There was significant decrease in Serum Total Protein, Serum Albumin & Serum globulin in Nephrotic patients when compared to Controls. The study finding conclude that the serum lipid profile shoed noticeable increase in the nephrotic syndrome in Indian patients. It also observed that nephrotic patients are having hyperlipidaemia. This hyperlipidaemia may progress in to the cardiovascular diseases. Hence the lipid profile in the nephrotic syndrome must be monitored for better management of the diseases.