Objective: To investigate the suitability of Butea monosprrma flower extract as colouring agent for paediatrics syrup. Method and Materials: The plant parts which are used in experimental work for investigating the suitability of Butea monosperma flower extract as colouring for paediatric syrup .1kg of dried Butea Monosperma flowers were weighed out and spread out in a thin layer. After authentication, a 1kg sample of Butea monosperma was washed for ten seconds in water (to avoid losing colour). Excess water was blotted from the sample with a clean towel, and dried in a hot air oven for four hours at 300 C. of the extraction procedure. Then the solvent for extraction (water, drug solvent ratio taken = 1:8) wasfilled. After completion of the extraction procedure the extract was taken out and evaporated up to semisolid consistency and then amount in percentages was determined in % w/w. Result: The plant Butea monosperma is very popular among the peoples of Northern Ghana, where the leaves are used in soups; and calyces for soft drinks and also used medicinally. It has been found to possess several health benefits the flower have a very rich orange colour, which this study aims at investigating its suitability as a colouring agent in pharmaceutical syrup Conclusion: the colour extract from Butea monosperma is found suitable as a pharmaceutical colouring agent, and then Tartrazine can be replaced with this natural source of colour, promoting the health of our people.