Each individual immune system is highly specific but extremely distant from other individuals. Based on recent technological advancement whole immune system analysis reveal different immune profiling for every individual. Herein, we clarified the detailed variation in the human immune system with coherence to their respective effecting factors. The most influencing factors include age, time, gender, heritable, non-heritable, non-pathogenic, pathogenic microbes, genetic makeup and environment. Correlating these factors analysis will help us to investigate and treat numerous immune pathological conditions with highest specificity at the doorstep of every individual in the near future.