Journal of Neurology and Neurorehabilitation Research

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Impact of early life experience on adult health.

Early life stress (ELS) causes multiple epigenetic modifications (e.g. methylation of genes and histones) in a developing child’s genome. Early life stress comes in various forms: Serious physical and mental abuse for example by parents, relatives, or caregivers; a poor social environment involving drug addicts and gang warfare; or loss of all parents and close relatives. This brief review is an attempt to update the information in the above-mentioned opus with a focus on in part on events in the brain and emphasizes that dissociable domains compose executive function

Author(s): David T. Denhardt