Histopathological assessment of the macerated Allium sativum (garlic) on cytoarchitectural alterations in alloxan (150mg/kg) induced diabetic rat liver was studied. Twenty five (25) weaning rats weighing between 105- 205g were divided into five (5) groups of 5 rats each. Group I and group II served as the normal control (NC) and diabetic control group (DC) respectively. The diabetic experimental groups III,IV and V were administered macerated preparation of Allium sativum (garlic) at a dose of 6.6g/kg and standard pellets orally for 7 ,14 and 21 days respectively. Thereafter, the animals were sacrificed, liver were weighed and fixed immediately in 10 % formal saline, transported to the laboratory, processed to paraffin wax, cut at 5 microns, stained using Heamatoxylin and Eosin technique and observed histopathologically under light microscope. The result revealed preserving cellular architecture, re-appearance of hyperplastic hepatocytes and cellular restoration, vascular dilatation and pyknotic nuclei in group III as mild, group IV as moderate restoration and group V as complete regeneration when compared to non-diabetic and diabetic control group that showed focal area of necrosis, vascular congestion, hyperplasia, vacuolation, inflammation and cellular degeneration. Statistical value in the weight of the body and liver were not significant at the value (p >0.05) compared to control. These findings are suggestive of a possible hepato-protective role played by the macerated preparation of Allium sativum (garlic) in single administration.