Histopathological effects of macerated Allium sativum (garlic) on cyto-architectural alterations in the kidney of alloxan (150mg/kg) induced diabetic rats was investigated. Twenty five (25) weaning rats weighing between 105- 205g were divided into five (5) groups of 5 rats each. Group I and group II served as the normal control (NC) and diabetic control group (DC) respectively. The diabetic experimental groups III,IV and V were administered macerated preparation of Allium sativum (garlic) at a dose of 6.6g/kg and standard pellets orally for 7,14 and 21 days respectively. Thereafter, the animals were sacrificed, kidney was extracted, weighed and fixed immediately in 10% formal saline, transported to the laboratory, processed to paraffin wax, cut at 5 microns, stained using Heamtoxylin and Eosin technique and observed histopathologically under light microscope. The result revealed, increase in cellular regeneration with prominent nuclear rearrangement in group III as slight, in group IV as moderate restoration and group V as complete restoration as compared to the normal non-diabetic group which revealed normal cellular architecture and diabetic control group II showed area of tubular necrosis, thickening and distortion of the basement membrane, glomerular damages and edematous convoluted tubules. Statistical value in the weight of the body and liver were not significant at the value (p >0.05) compared to control. These findings are suggestive of possible anti-diabetic and nephro-protective potentials played by the macerated preparation of Allium sativum (garlic) on kidney in single administration.