Brucella species is known to cause abortion in infected mammals. This has been attributed to the localization of infection in uterine and placental tissues. The present study was conducted on specimens taken from uterus of Brucella sp. culture positive cases of dogs and cows. The aim of the study was to establish the histological changes seen in uterine tissue in acute cases of brucellosis. Routine staining with hematoxylin and eosin (H&E) was done and the brucella positive samples were compared with normal uterine tissue samples, which were used as control specimens.The study revealed marked changes, in the form of mononuclear cell infiltrations, fibrosis, and calcification of tissue. It may be concluded from the findings that brucellosis causes marked histological changes in the uterine tissue of infected mammals.