The present study is the development of colon targeted matrix tablets of the drug Naproxen, a NSAIDS. Designed to prolong the release for sustained effect. Different formulation (MT1 TO MT3) batches were made with the help of different polymers and their different proportions (Guar Gum, Xanthan Gum) with the help of Wet granulation techniques. The prepared matrix tablets were evaluated in terms of their pre-compression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, invitro drug release. From this study we concluded that the batch MT3 shows good results then the other batches. The batch MT3 shows maximum prolong release up to 12 hrs.