Asian Journal of Biomedical and Pharmaceutical Sciences

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Evaluation of the Ocular Effects of Clonidine Following Therapuetic Use

Clonidine hydrochloride is a potent centrally acting antihypertensive agent, having vagotonic effect, lowering blood pressure by stimulating α2-receptors in the brain which decreases the peripheral resistance. Apart from its lowering of intra-ocular pressure, no attention has been focused on its effects on any other visual functions. This study was undertaken to investigate the ocular manifestations or signs after therapeutic use of clonidine. Results showed that the pupillary diameter (PD), amplitude of accommodation(AA) and accommodative-convergence/accommodation (AC/A) ratio decreased by 31%, 24.5% and 69% respectively; while the visual acuity (VA) and the near point of convergence (NPC) increased by 65% and 16% respectively. Furthermore, there were significant and varying changes in the phoria status. The net effect of clonidine on visual functions is implosion of vision due to convergence insufficiency and excessive accommodation

Author(s): GWE S. A., Nwobodo N. N., Nwadike K. N., Ebo E. N., Agbata C