Short Communication - Journal of Clinical Pathology and Laboratory Medicine (2018) Volume 2, Issue 1
Evaluation of diagnostic tests in human health and disease.
Evaluation of diagnostic tests and biomedical data that have promised detection of early disease progression have raised concerns with under-diagnosis of various chronic diseases associated with the prevalence of various global chronic diseases. Diagnostic tests and plasma analyte analysis do not determine nuclear-mitochondria defects with discoveries in clinical eipgenetics that identify the gene Sirtuin 1 to be defective and to be involved in toxic immune reactions relevant to mitophagy. Proteome blood analysis is now an important diagnostic procedure in medicine with existing proteomic biomarkers correlated with early disease progression in health and disease. Sirtuin 1 analysis in plasma and body fluids is essential to determine the importance of diagnostic clinical biochemisty tests and will allow early diagnosis of disease progression that involves cardiovascular disease, non alcoholic fatty liver disease, metabolic disease and neurodegenerative diseases.Author(s): Ian James Martins