Asian Journal of Biomedical and Pharmaceutical Sciences

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Evaluation of Anticonvulsant Potential of Bryophyllum Pinnatum in Experimental Animals

The present study was undertaken to evaluate the anticonvulsant potential of Bryophyllum pinnatum in mice. We studied the effects of ethanolic extract of the leaves of Bryophyllum pinnatum against maximal electroshock (MES) induced convulsions and Pentylenetetrazole(PTZ) seizure model in mice. Parameters observed in MES model were duration of hind limb tonic extension (HLTE), the total recovery time and percentage protection. In the PTZ model, the parameters observed were onset of clonic convulsions (latency period), duration of clonic phase, percentage reduction of clonic phase and percentage mortality. In the MES induced convulsion Phenytoin (25mg/ kg) was used as standard drug and in PTZ model Diazepam (4mg/kg) was used as the standard drug. Extract was used in 200, 300 and 400 mg/kg doses. Results obtained in this study substantiate the anticonvulsant effect of ethanolic extract of Bryophyllum pinnatum leaves.

Author(s): Arijit Dutta, Chimi Handique, Mangala Lahkar