Asian Journal of Biomedical and Pharmaceutical Sciences

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Effect of Sustained Release Solid Dispersions on Dissolution of Poorly Soluble Drug

There are various techniques to control the release rate of the drugs, among which, controlling dissolution rate is most popular due to its success and low cost. Fenofibrate is a lipid lowering drug used in the treatment of hyperlipidemia, there are some reports on solid dispersions of Fenofibrate to enhance bioavailability but sustained released solid dispersion still untouched. The present study deals with preparation and evaluation of sustained release solid dispersions of Fenofibrate using retarding polymers. Solid dispersions were prepared by solvent evaporation techniques using EVA, EU (RL) – 100 and EC. Drug polymer interactions were studied by I.R. and in–vitro drug release was performed at 37 ± 0.50C. The IR studies confirmed absence of any possible interaction. Incorporation of PEG 6000 in solid dispersions increases the release of Fenofibrate. However, the release of Fenofibrate was retarded with an increasing the concentration of EC, EU RL 100 and EVA & sustained the release of drug.

Author(s): Sarkar B, Jain Devananda, Agarwal A, Panwar A.S