Grasscutter (Thryonomis swinderianus Temminck, 1827), breeding has to face with numerous affections among which feeding is one. Since there is a need to improve the knowledge on the physiology of grasscutter serum biochemical parameters and parasites of digestive tract were determined using 32 grasscutters of ten months old, submitted to two different diets. Except creatinine, cholesterol and urea, the level of other parameters as total protein, and total bilirubin was significantly higher with granulate diet (p<0.05). Regarding ionic parameters, only the level of calcium, potassium and phosphorus were significantly different (p<0.05). As for as concerned enzymes, no significant catalytic activities difference was noticed (p>0.05). The proportion of Coccidia was significantly higher with grass cuter receiving forage (p<0.001), with the proportion of Trichuris for which no difference was observed.