Piroxicam is a non steroidal anti-inflammatory drug with analgesic properties. The purpose of this study was to develop a mucoadhesive fast disintegrating tablet of poorly soluble Piroxicam by direct compression technique using superdisintegrant sodium starch glycolate and interactive mixture was characterized by physicochemical parameters. A Box Behnken design was applied to systematically optimize the drug disintegration time. Independent variables studied were the amount of Disintegrant (X1), amount of Bioadhesive (X2) and amount of Binder (X3). The dependent variables were Hardness (Kg/cm2) (Y1), Disintegration time (sec), (Y2) friability (%) (Y3) and wetting time (sec) (Y4). The prepared tablets were evaluated physical properties hardness, friability, disintegration time, wetting time and In-vitro drug release.