Duodenal ulcer perforation is the second most common abdominal emergency in our study. After invention of the H2 blockers and proton pump inhibitors the role of elective surgery for duodenal ulcer has been drastically decreasing, but the incidence of perforation is not much changing. All the patients are informed consents. The 80 peptic ulcer disease patients were enrolled in to the study. The age group of the patients are from 20-70 years. The patients visited to Out Patient Department (OPD) and in-patient department (IPD) of a tertiary care hospital in North India were considered in the study. All the patient’s clinical history were collected. Also the complete physical examination was done. The incidence of perforation is more in middle aged males. This trend can be attributed to their increased predisposition to smoking and alcohol. It is noted that post operative pulmonary complications and wound infection are more in the alcoholics and smokers.