Asian Journal of Biomedical and Pharmaceutical Sciences

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Comparative Success of Natural Superdisintegrant over Synthetic Superdisintegrants in Fast Disintegrating Tablets

In the present study, fast disintegrating tablets of Amlodipine Besylate were prepared by direct compression methods for better patient compliance and immediate action in angina. The tablets were prepared by using synthetic superdisintegrants (Crospovidone and Croscarmellose sodium) and natural superdisintegrant (Plantago ovata) at different concentrations. The prepared tablets were evaluated for weight variation, hardness, Friability, disintegration time, wetting time, dispersion test, drug content and in vitro dissolution tests. The tablets were subjected for stability study at 25°C /60% RH and 40°C/ 75% RH. The results clearly shows Natural superdisintegrant (husk of Plantago ovata) requires less disintegration time as compared to synthetic superdisintegrants. Hence present study reveals that the fast disintegrating tablets prepared by using husk of Plantago ovata as superdisintegrants having better appearance and it having rapid disintegration time.

Author(s): Chetan G. Patil, Shivprasad H. Majumdar