Nephrotic syndrome is commonest renal diseases in developing country. The nephrotic syndrome is a clinical syndrome complex characterized by a number of renal and extra renal features, the most prominent of which are proteinuria >3.5g/1.73m3/24 h (in practice >3.0-3.5 g/24 h), hyperlipidemia, lipiduria, and hyper coaguability. The present study was planned in North Indian Hospital. The total 20 patients referred to Out-Patient Department (OPD) and in-patient department (IPD). All the patients were subjected to renal biopsy. The Swelling of feet and puffiness of face is found in about 8 patients out of 20. Weakness, loss of appetite, and generalized bodyache is seen in 4 patients. Distension of abdomen and difficulty in breathing is observed in 3 patients. Pallor and dizziness is seen in 2 cases and Decreased urinary volume is observed in 3 patients. The most common primary glomerular diseases causing nephrotic syndrome in children and adults are minimal change diseases and membranous glomerulonephritis, respectively.