The direct effects of Petiveria alliacea, and Flueggae virosa were tested on the life cycle of Musca domestica. Leaf powders of P. alliacea, and F. virosa at various concentrations of 2, 5, 10, and 15 % (w/w) were added to the mixture of rice and fish paste and tested on the larval duration, pupation percent, pupal weight, pupal duration, and adult emergence percent. Diets treated with 2,5, 10 and 15% concentration of P. alliacea, and F. virosa generally increased the duration of the third instar larva by 50, 75, 25, 75and 75% in comparison with the control. Moreover, pupal duration was lengthened while total development time was increased by 15% concentration of P. alliacea, and F. virosa. In addition, a 15% concentration of P. alliacea and F. virosa, reduced the mean emergence of adults by 10.0, 9.0, 11.9, 11.9 and 13.8% including the corresponding weights of adult M. domestica by 13.9, 15.5, 19.4, 13.2 and 19.4% respectively. The powder materials of P. alliacea and F. virosa appear to have promising biological effects in controlling the developmental stages of M. domestica.