Asian Journal of Biomedical and Pharmaceutical Sciences

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Association of age related severity in oxidative stress and blood urea nitrogen levels in patients with dementia: A coastal Karnataka study

Introduction: It has been shown that occurrence of dementia increases with age. Oxidative stress has been implicated in the development of dementia. In the present work, we measured malondialdehyde (MDA), total thiols and other routine biochemical parameters in dementia patients to establish a relationship between them. Method: Study was carried out in 51 dementia patients and 30 healthy controls. The serum from patients and controls were analyzed for MDA, protein thiols, lipid profile, RBS and BUN by spectrophotometric methods. Results: There was a significant increase in MDA level (p<0.001) and blood urea nitrogen (BUN) level (p<0.001) and decrease in thiols levels (p<0.001) in dementia patients compared to healthy controls. There was a positive correlation between levels of MDA and age of patients (r=0.542, p<0.001). Negative correlation was observed between total thiols and age of the patients. (r= - 0.420, p<0.05) and total thiols and blood urea nitrogen (r= -0.343, p<0.01). Conclusion: In line with previous studies, our study has shown increased oxidative damage in dementia patients irrespective of their etiology. This study also explores the relationship between increased BUN concentration and dementia.

Author(s): Abhishek Chaturvedi, Archana Natarajan, Vivek Sharma, Nagalakshmi Yaparthy, Jeevan K Shetty, Devaramane Virupaksha, Panambur V Bhandary, Mungli Prakash