Asian Journal of Biomedical and Pharmaceutical Sciences

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Association between Serum Lipid Profile and Glycated Hemoglobin in Pre-diabetic Individuals

Background: Pre-diabetes is a condition in which the blood glucose level is above normal but below the diagnostic threshold for diabetes mellitus. Impaired lipid profile i.e dyslipidemia is commonly associated with CVD in type 2 diabetes and can also occur in pre-diabetics.
Material and Method: The present study was conducted on 50 patients with no sign and symptoms of diabetes mellitus with HbA1c level between 5.7%–6.4%. Pre-diabetic individuals were categorized into 2 groups according to their fasting blood sugar level, FBS?110 mg/dl as normal and for impaired fasting glucose between 110–125 mg/dl. HbA1c was analyzed by high pressure liquid chromatography (Biorad D10). Fasting blood sugar and lipid profile were analyzed on Vitros 250 dry chemistry fully autoanalyzer.
Result: There was no significant difference in total cholesterol, triglyceride, HDL-c, VLDL, LDL, TC/HDL and LDL/HDL in patients with normal and impaired fasting glucose level with HbA1c between 5.7%–6.4%
Conclusion: Relationship between high risk range of HbA1c (5.7% - 6.4%) and CVD mortality is still not clear. Studies on large population are required to find out whether estimation of lipid profile in pre-diabetic should be used routinely or not in pre-diabetic patients..

Author(s): Singh K, Srivastava N, Singh RL, Mahdi AA