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Research Paper - Asian Journal of Biomedical and Pharmaceutical Sciences (2018) Volume 8, Issue 64
Applying Experimental Design and Optimization of Studying the Hydrophilic Matrix Sustained-Release Tablets of Felodipine
Objective: Felodipine is a calcium channel blocker used for hypertensive and unstable angina treatments. The sustained release formulations of felodipine have advantages of achieving good therapeutic effects, increasing a bioavailability, decreasing dosing times per day and reducing side effects. The aim of our study was to study the formulation screening, then use an experiment design for formulating a hydrophilic matrix sustained release Tablet of felodipine. Methods: The optimization process had the influences of the chosen excipients (including HPMC E4M, HPMC E15LV) on the drug release. Three dependent variables were percentages of released felodipine at the sampling times 2 h, 6 h, 10 h (Y2, Y6, Y10, respectively). Results: The release profile from the optimized formula almost met the predicted release profile and similar to reference Tablets. The kinetics of drug release the optimized Tablets and reference Tablets were also followed the Korsmeyer-Peppas model. Conclusion: The optimized formula was obtained, and the in vitro release profile was similar to the predicted profile and reference Tablets.
Author(s): Duyen Nguyen Thi Thanh, Duc Hoang Van, MinhVo Xuan, Xuan Dam Thanh, Tung Bui Thanh