Asian Journal of Biomedical and Pharmaceutical Sciences

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Antistress Potential of Simvastatins in Chronic Immobilization Stress

Objective: A pharmacological study to explore Anti stress Potential of Simvastatins in stress produced models of mice.
Method and Material
Male Albino mice weighing between 22-30 g of weight were obtained from B.R.N.C.P. Mandsaur Animal House. The animals were stabilized for 1 week; they were maintained in standard condition at room temp; 60 ± 5% relative humidity and 12 h light dark cycle. They had free access to food and water. Animals were acclimatized to laboratory conditions before the experiment. All the experiments were carried out between 09:00 and 15:00 h. The experimental protocols were approved by Institutional Animal Ethics Committee of B. R. Nahata College of Pharmacy, Mandsaur, (M.P.).1
Chronic Immobilization Stress- The animals in all the groups except control (normal) were subjected to immobilization stress daily in a prone position for 150 min for 5 consecutive days using simple adhesive tape (chronic stress). Animals were released by removing the tape after moistening with acetone.2
Result: With the help of investigation of biochemical parameters of different groups of animals we found that simvavastatin significantly lowered the stress and stressor.
Conclusion: Simvastatin significantly suppressed the stress.

Author(s): Patley C, Patley R, Singh N