Asian Journal of Biomedical and Pharmaceutical Sciences

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Antihyperlipideamic effect of Solanum trilobatum L. leaves extract on streptozotocin induced diabetic rats

The present study was undertaken as antihyperlipidaemic effect of an aqueous leaves extract of Solanum trilobatum L. on streptozotocin (STZ)- induced diabetic rats. Repeated administration of the leaves extract of S.trilobatum (100mg and 200mg/kg b.w) for 21 days resulted in significant reduction in serum and tissue triglycerides, cholesterol, free fatty acids and phospholipids in STZ diabetic rats. In addition to that, significant (P<0.05) decrease in high density lipoprotein (HDL) whereas significant increase (P<0.05) in low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were observed in STZ diabetic rats, which were normalized after 21 days of leaves extract treatment. The leaves extract at a dose of 200mg/kg.body wt. showed much significant antihyperlipidaemic effect than at the dose of 100mg/kg-body wt. The study was compared with a standard drug, tolbutamide (100mg/kg b.w).

Author(s): Kumar Ganesan, Maheswaran Ramasamy, Sharmila Banu Gani