Depression is one of the leading causes for many disorders in both developed and developing countries. Cinnamomum camphora oil (CCO) has been referred in Indian traditional medicine system for the treatment of various diseases which includes its antidepressant activity. Evaluation of antidepressant activity was done by using 3 doses of CCO in 2 invivo models. Group I received normal saline, group II received standard drug, group III received 250 mg/kg, group IV 500 mg/kg and group V 750 mg/kg of CCO. Animals treated with 3 doses of CCO showed decrease in their immobility times in Forced Swim Test (FST) & Tail Suspension test (TST) which was significant when compared with control.