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Journal of Materials Science and Nanotechnology | Volume: 2
August 20-21, 2018 | Paris, France
Materials Science and Materials Chemistry
International Conference on
The potential application of functionalized ZnO nanorod as electrochemical (Glucose and metal ions)
biosensors for intracellular environment
Muhammad H Asif, B Danielssonl
COMSATS University, Pakistan
T
he nanostructure of zinc oxide (ZnO) such as nanorods and
nanowires has interesting nanosurfaces in addition to its
bulk properties. ZnO has attracted much interest because of
its unique piezoelectric, semiconducting, catalytic properties
and being biosafe and biocompatible morphology combined
with the easiness of growth. This implies that ZnO has a wide
range of applications in optoelectronics, sensors, transducers,
energy conversion and medical sciences. This abstract relates
specifically to electrochemical biosensors based on single
and multiple ZnO nanorods especially on a flexible substrate
for the extra/intracellular environment. Functionalized zinc
oxide nanostructure was used in biological, biochemical and
chemical applications. One of the properties is that these
nanostructures are very suitable for intracellularmeasurements
of pH, metal ions, glucose and also for cholesterol using
potentiometric measurements techniques. To adjust the
sensor for intracellular measurements, the ZnO nanorods
were grown on the tip of a borosilicate glass capillary (0.7µm
in diameter) and functionalized with polymeric membrane
or enzymes for intracellular selective metal ion sensors. The
sensor in this study was used to detect and monitor real
changes of metal ions and glucose across human fat cells and
frog cells using changes in the electrochemical potential at the
interface in the intracellular microenvironment. The fabrication
of such type of device aims to explain the methodology
of ions sensing using functionalized ZnO nanorods for the
intracellular environment. This nanoelectrode device paves
the way to enable analytical measurements in single living cells
e:
asifhassan@ciitlahore.edu.pk