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Virology Research Journal
|
Volume 2
Page 43
allied
academies
IMMUNOLOGY AND CELL BIOLOGY
BACTERIOLOGY AND INFECTIOUS DISEASES
&
Global Summit on
Global Congress on
J u n e 2 5 - 2 6 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s
Joint Event on
GUT AND INTEGRATED PATHOPHYSIOLOGY OF IMMUNE RESPONSE;
OBSERVATIONS FROM EXPERIMENTS IN ORAL TOLERANCE IN MICE AND
THE RESPONSE ASSOCIATED WITH A MODEL OF METABOLIC SYNDROME
SURGERY
Giovani Marino Favero
State University of Ponta Grossa, Brazil
T
he gut mucosa is the place that most contact with foreign antigenic proteins occurs and forms with the immune system an
integrated, dynamic and adaptive complex that has evolved to provide effective digestion and defense. The whole intestinal
area is 100-fold larger than the skin, presents the largest amount of lymphoid tissue of the body and the more number of activated
lymphocytes. The Peyer´s patches and the lamina propria of the gut present a very large number of T cells. Immunoglobulin
production, especially IgA, that is the only antibody secreted by mucosal, offers the first protection to neonates. For the
experiment with Oral Tolerance proposed an protocol in adult Swiss mice by oral administration of a recombinant dermo-necrotic
toxin of brown spider Loxosceles intermedia (LiRecDT1) and its mutated form (LiRecDT1H12A) for three weeks. Our results
demonstrated evidences of tolerance induction through decrease in IgG anti-dermonecrotic toxin levels, paw edema reduction
and increased survey in 24h after challenge. All statistical analysis was performed using ANOVA following Bonferroni’s pos hoc
test. Related to bowel surgery readjustment we observed that the removal of the greater omentum decreases the secretion of
cytokines, particularly IL-6, regressing other diseases associated with obesity such as bronchitis. In conclusion, the intestine can
be considered the main immune organ of the body and this association between immunity and digestion begin prior to birth and
mediate allergic responses and/or tolerance throughout the life of the individual.
gmfavero@uepg.brVirol Res J 2018, Volume 2