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Research and Reports in Gynecology and Obstetrics | Volume 3
November 14-15, 2019 | Singapore
Obstetrics and Gynecology
4th International Conference on
Hypertensive disorders of pregnancy are associated with an inflammatory state: Evidence
from hematological findings and cytokine levels
Mtali Y S, Lyimo M A, Lucio L and Massawe S N
Muhimbili University of Health and Allied Sciences, Tanzania
Abnormalities of blood cell counts and of cytokine profiles
in women with hypertensive disorders of pregnancy
(HDP) have been reported in several studies. Although
their cause-effect relationships to HDP are not yet clear,
detecting and monitoring these alterations can be of use
for prognosis and management of HDP. This study aimed
to determine hematological, coagulation and cytokine
profiles in hypertensive as compared to normotensive
pregnancy and identifying correlations between these
profiles. Hospital-based comparative cross-sectional
study conducted from September 2017 to February 2018.
There were two groups: normotensive pregnant women
(n=77) attending the antenatal clinic and hypertensive
pregnant women (n=76) admitted to the maternity block of
Muhimbili National Hospital. Hematological and cytokine
parameters were compared between these groups using
Student’s independent t-test when the data were normally
distributed; and the Mann–Whitney U-test when the data
were not normally distributed. Kruskal Wallis with Dunn’s
multiple comparison tests was run for subgroup analysis
and correlation studies were done using Spearman ranking.
Hemoglobin levels were slightly but significantly lower,
(P < 0.01) in women with HDP compared to normotensive (N)
women; the samewas true for platelet counts (P < 0.001). The
red cell distribution width (RDW) was slightly but significantly
higher in HDP than in normotensive. Neutrophil counts and
Interleukin 6 (IL-6) levels were significantly (P < 0.001) higher
in HDP than in normotensive; and within HDP IL-6 levels
increased with increasing severity of HDP. A novel remarkable
finding was that eosinophil counts, normal in normotensives,
were lower and lower with increasing severity of HDP, to the
point that they were nearly absent in women with eclampsia.
There are significant changes in hematological, cytokine
and coagulation parameters in pregnant women with
hypertensive disorders compared to normotensive pregnant
women. The picture that emerges is that of an inflammatory
state associated with hypertensive disorders of pregnancy.
Speaker Biography
Mtali Y S has a Bachelor of Science in health laboratory science and recently
defended his master’s by research in Hematology at Muhimbili University
of Health and allied sciences. He also serves as Tutorial assistant at the
same university. He is an eminent researcher with one publication in a
peer-reviewed journal and a member of Muhimbili university scientific
conferences organizing committee.
e:
Notes:
Mtali Y S et al., Res Rep Gynaecol Obstet, Volume:3
DOI: 10.35841/2591-7366-C3-008