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academies
March 07-09, 2019 | London, UK
2nd International Conference on
7th International Conference on
Food Safety and Hygiene
Nutrition, Food Science and Technology
Joint Event
&
Journal of Food Technology and Preservation | Volume 3
Probiotics, diet and cancer therapy: A promising synergistic approach
Claudia Gravaghi
Mayfair Doctors, UK
In the last decade, interactions between human micro-
biome and tumour have attracted much interest in trying
to understand the characteristics of complex microbial
communities, as well as their possible mechanisms through
which they are involved in cancer prevention, carcinogenesis
and anti-cancer therapy. Cancer patients can benefit from
different types of therapeutic strategies. However, the toxicities
associated with these therapies can cause dysbiosis, colitis and
IBS symptoms, affecting the patient’s quality of life and the
response to therapy. Several studies identify a com-positional
and functional imbalance in the intestinal microbial community
associated with GI mucositis induced by chemotherapy.
Furthermore, signs of a previous dysbiosis may also occur
due to the effect of gastric tumours on the digestive system,
increasing the risk of systemic infections. It is well known
that there are several dietary interventions aimed to improve
dysbiosis and IBS symptoms. In this contest, a dietary regime
containing low glycaemic index foods, high in soluble fibre,
adequate in protein, high in omega-3 containing foods (wild
fish and low in omega-6 nuts), dairy free, red and cured meat
free was effective in reducing or eliminating IBS symptoms,
such as diarrhoea/constipation episodes, and bloating in 80%
of the patients analysed (n=146, age18-64, 120 women, 26
men). The purpose of this study was to see if the same dietary
regime, in combination with the administration of probiotics
containing lactobacillus ramnosus, applied to a small number of
pancreatic cancer patients at the beginning of their first cycle of
chemotherapy will improve the common gastrointestinal side
effects to prevent weight loss and dysbiosis preliminary results
(patients n=10, age 40-75 without metastatic tumours) show
that all the patients experience only short diarrheal episodes
followed by constipation and tiredness in the two days after
the chemotherapy but no further digestive symptoms in the
following days or weight loss.
e:
J Food Technol Pres, Volume 3
DOI: 10.4066/2591-796X-C1-006