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allied
academies
Journal of Microbiology: Current Research | Volume 2
November 01-02, 2018 | London, UK
7
th
European
Clinical Microbiology Congress
4
th
International Conference on
Ophthalmology and Eye Disorder
Joint Event
&
Direct evidence of viral infection and mitochondrial alterations in the brain of fetuses at high risk for
schizophrenia
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
T
here is increasingevidences that favor theprenatal beginning
of schizophrenia. Theseevidencespoint toward intra-uterine
environmental factors that act specifically during the second
pregnancy trimester producing a direct damage of the brain
of the fetus. The current available technology doesn’t allow
observing what is happening at cellular level since the human
brain is not exposed to a direct analysis in that stage of the life
in subjects at high risk of developing schizophrenia. Methods.
In 1977, we began a direct electron microscopic research of the
brain of fetuses at high risk from schizophrenicmothers in order
to finding differences at cellular level in relation to controls.
Results:
In these studies we have observed within the nuclei of
neurons thepresenceof completeand incomplete viral particles
that reacted in positive form with antibodies to herpes simplex
hominis type I [HSV1] virus and mitochondria alterations.
Conclusion:
The importance of these findings can have practical
applications in the prevention of the illness keeping in mind
its direct relation to the aetiology and physiopathology of
schizophrenia. A study of the gametes or the amniotic fluid
cells in women at risk of having a schizophrenic offspring
is considered. Of being observed the same alterations that
those observed previously in the cells of the brain of the
studied foetuses, it would intend to these women in risk of
having a schizophrenia descendant, previous information
of the results, the voluntary medical interruption of
the pregnancy or an early anti HSV1 viral treatment as
preventive measure of the later development of the illness
.
e:
segundo@infomed.sld.cuClinical Microbiology and Eye 2018, Volume 2
DOI: 10.4066/2591-8036-C1-003