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O c t o b e r 1 9 - 2 0 , 2 0 1 8 | T o k y o , J a p a n
Pharma Congress 2018 & Molecular Medicine 2018
& Psychiatric Disorders 2018
Asian Journal of Biomedical and Pharmaceutical Sciences
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ISSN: 2249-622X
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Volume 8
International Conference on
PHARMACEUTICS AND NOVEL DRUG DELIVERY SYSTEMS
19
th
International Conference on
CELLULAR AND MOLECULAR MEDICINE
19
th
Annual Congress on
PSYCHIATRY AND PSYCHIATRIC DISORDERS
&
&
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
alliedacademies.comYEARS
Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C3-009
DIRECT EVIDENCE OF VIRAL INFECTION AND MITOCHONDRIAL
ALTERATIONS IN THE BRAIN OF FETUSES AT HIGH RISK FOR
SCHIZOPHRENIA
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
T
here is increasing evidences that favor the prenatal beginning of schizophrenia. These evidences point towards intra-uterine
environmental factors that act specifically during the second pregnancy trimester producing a direct damage of the brain of
the fetus. The current available technology doesn’t allow observing what is happening at cellular level since the human brain is
not exposed to a direct analysis in that stage of the life in subjects at high risk of developing schizophrenia. In 1977, we began
a direct electron microscopic research of the brain of fetuses at high risk from schizophrenic mothers in order to finding dif-
ferences at cellular level in relation to controls. In these studies we have observed within the nuclei of neurons the presence of
complete and incomplete viral particles that reacted in positive form with antibodies to herpes simplex hominis type I [HSV1]
virus, and mitochondria alterations. The importance of these findings can have practical applications in the prevention of the
illness keeping in mind its direct relation to the aetiology and physiopathology of schizophrenia. A study of the gametes or the
amniotic fluid cells in women at risk of having a schizophrenic offspring is considered. Of being observed the same alterations
that those observed previously in the cells of the brain of the studied foetuses, it would intend to these women in risk of having
a schizophrenia descendant, previous information of the results, the voluntary medical interruption of the pregnancy or an early
anti HSV1 viral treatment as preventive measure of the later development of the illness.