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S e p t e m b e r 1 0 - 1 1 , 2 0 1 8 | D u b l i n , I r e l a n d
Pharma Chem Congress 2018 & Toxicology Congress 2018
Note:
Page 16
allied
academies
TOXICOLOGY AND PHARMACOLOGY
PHARMACEUTICAL CHEMISTRY & DRUG DISCOVERY
&
Global Congress on
International Conference on
Joint Event on
Asian Journal of Biomedical and Pharmaceutical Sciences
|
Volume 8
Yu-Cheng Kuo, Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C2-004
MERIDIAN ON PHARMACOLOGY AND
NEW DRUG DEVELOPMENT
C
ompared to conventional western medicine based on anatomy and chemistry
particles, traditional Chinese medicine physicians practice clinic following “Chi”.
What is “Chi”? After 25 years study of pulse diagnosis, we defined it as wave or
periodic signal. Under this definition, we could recognize the reality of meridians
or harmonics between time and frequency domain phenomenon with Fourier
transform. Moreover, we could discover the basis of Chinese Medicine based on the
mathematics and physics of meridian. With second harmonic generation law and the
energy conservation law on meridians, we proved the core mathematic property and
philosophy of the Chinese five elements theorem. From the balance of the forces
on the artery wall by Newton’s law of mechanics, we derived the radial resonance
equation to describe the physical property of the blood pressure wave propagation
and transmission in the arteries. Meanwhile, radial resonance theorem explains
the physiology of circulation system and builds up the basis of pulse diagnosis on
meridians. Based on the results obtained from both animal and clinical experiments,
we verified the pulse diagnostic method on meridians recorded in medical literature
classic and designed a pulse apparatus according to this meridian principle.
Through the pulse diagnostic apparatus, we could map the meridians to harmonics
and quantitatively analyze the pathological excess or deficiency of the meridians
including the five zang-organs and six fu organs of the patient (pathological matrix).
In addition, a series of pharmacology research analyses of acupuncture, Chinese
herbs, herbs prescription formula and western drugs on the reinforcing or reducing
effect of meridians were being carried out. Even laser acupuncture could be found
the effects on harmonics or meridians which described as VAS or resonance therapy
in Europe. On the other hand, with matrix operation on harmonics, we were able to
simulate the whole make up meridian function of a prescription formula which is
composed of several herbs (pharmacological matrix). In clinic, we found that the
pathological indicator on meridians-HCV (coefficient of variations of harmonics
magnitude) could quantitatively reflect the severity of diseases and evaluate the
outcome of patients. From health to death, life struggles between convergence and
divergent of negative entropy revealed by the HCV of meridian. Combining the HCV,
the pathological and pharmacological inverse matrixes, we developed an algorithm
for the AI system to give prescription following the Chinese Medicine Bible: Shang
Han Za Bing Lun, such as the white tiger and green dragon formulae. This is also the
basis to give acupuncture or laser acupuncture prescription. With Meridian theory,
we discovered a series of compounds from Cnidii Fructus which a simplest herb
formula is described in Shang Han Za Bing Lun. Including BMX, these compounds
have been identified asHDAC8 inhibitor.Meanwhile, we developed these compounds
guided by the meridian effect on liver and gallbladder which dominate the blood
perfusion of brain recorded in Chinese Medicine classic literature. As we expected,
BMX passes through BBB (blood brain barrier) in our study. These results provide
confidence to us for brain cancer therapy and completed USFDA pre-IND meeting
this year. As light, life and medicine owns the duality of particle and wave.
Biography
Yu-Cheng Kuo is a Chinese Medical Doctor,
Assistant Professor and Editor in
Chief for Journal
of Applied Sciences and Research.
He is also the
Master of Pharmacology and the PhD holder of
Electric Engineering in Biomedical field. He teaches
Pharmacology in Taipei Medical University and
pulse diagnosis in Chinese Medicine University in
Taiwan. Since 2007, he has always been invited
to give speech in the international conference
for the research of pulse diagnosis and scientific
modernization of Chinese Medicine. Meanwhile,
he applied these studies to new drug development
and invested a biomedical company– Nature Wise
which owns the specific HDAC8 inhibitors and can
pass the blood brain barrier.
yucheng.kuo@msa.hinet.netYu-Cheng Kuo
Taipei Medical University, Taiwan