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Journal of Materials Science and Nanotechnology | Volume 3
May 16-17, 2019 | Prague, Czech Republic
2
nd
International Conference on
22
nd
International Conference on
Nanomaterials and Nanotechnology
Advanced Nanoscience and Nanotechnology
Joint Event
&
Mater Sci Nanotechnol, Volume 3
M
ultifunctional nanoparticles are promising bimodal
tracers for noninvasive diagnosis and treatment of
cancer and inflammatory diseases
in vitro
and
in vivo
. The
design of bio-functionalized colloidal nanoparticles needs
careful optimization of size and shape, optical and magnetic
properties, and efficient conjugation with homing ligands
to improve the signal amplification and target selectivity
toward malignant cells. One of the greatest challenges in
designing nanoparticles functionalized with homing peptides
and proteins to optimize molecular recognition resides in
the possibility to finely control the ligand orientation on the
nanoparticle surface.
Figure1: Magnetic nanoparticles functionalized with
Trastuzumab or Ab fragments for targeting and treatment of
breast cancer cells
in vitro
and
in vivo
To support the research in new drug delivery nanosystems,
in the past few years new administration methods of
nanoparticles rather than traditional intravenous ones
have been explored. This is a highly innovative approach
that is nearly unexplored at present. Because of parenteral
administration draw-backs, alternative administration routes
have been investigated. Among all, the oral and topical
administration are the most interesting to obtain a local effect
and gain a better patient’s compliance.
Speaker Biography
Miriam Colombo obtained her master’s degree in 2008 in Medicinal
Chemistry and Technology at the University of Milano with experimental
thesis in the Nanobiotechnology and she made the PhD in Biology in
2012 at the University of Milano-Bicocca. In 2010, she worked in the lab
of prof. W. Parak, Marburg, Germany. In January 2009, she was awarded
of a 12+24 months fellowship in the field of Medical Sciences. From
September 2013, she is a researcher in clinical biochemistry (BIO/12), at
the Department of Biotechnology and Bioscience of University of Milano-
Bicocca. She is author of 70 scientific publications on peer-reviewed
international journals and official H-Index (Scopus): 22.
e:
Miriam.colombo@unimib.itMiriam Colombo
University of Milano-Bicocca, Italy
Bio-functionalized colloidal nanoparticles for therapeutic
applications