materials-chemistry-2018-scientifictracks

Page 13

Notes:

allied

academies

Journal of Materials Science and Nanotechnology | Volume: 2

August 20-21, 2018 | Paris, France

Materials Science and Materials Chemistry

International Conference on

Multifunctional nanoparticle for imaging and targeting cellular delivery

Oara Neumann

Rice University, USA

ultifunctional

plasmonic

nanostructures

have

enormous potential in the treatment of solid tumours;

however, tracking particles with drug cargo and triggering the

release of the cargo in mapped tumours is still impossible.

To overcome this challenge, we have developed an MRI and

fluorescent active nanostructure nanomatryoshka. This new

nanostructure with IR plasmonic signatures is composed of a

50 nmAu core surrounded by dyemolecules andGd(III)-DOTA

chelate doped SiO

inner-shell and an outer Au shell. The

experimental results demonstrate an enhanced T1 relaxation

(r1 ~ 24 mM-1 s-1 at 4.7 T) compared to the clinical Gd(III)-

DOTA chelating agents (r1 ~ 4 mM-1 s-1). Further, this design

preserves the fluorescence signal (65%) after 24 hours of

exposure, leading to enhanced fluorescence photostability

(23x). This dual-imaging functionality nanosystem increases

MRI sensitivity by concentrating Gd(III) ions into the Gd-

NMs, reduces the potential toxicity of Gd(III) ions and dye

molecules by preventing their release in vivo through

the outer Au shell protection, and the terminal gold layer

surface can then be functionalized to increase cellular

uptake, circulation time, or thermal drug-release properties.

Speaker Biography

Oara Neumann is the J. Evans Atwell-Welch research scientist at Rice University. She has

completed her PhD and Postdoctoral study in Applied Physics at Rice University, an MSc

in Chemical Physics from Weizmann Institute of Science, Israel and an MSc in Analytical

Chemistry from Bucharest University, Romania. She is the pioneer of nanoparticle-based

solar thermal applications. She holds several patents and she has published more than 24

referred articles and has an h-index of 16.