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Ann Clin Trials Vaccines Res. 2017 | Volume 1 Issue 2
Global Vaccines & Vaccination Summit & B2B
November 01-02, 2017 | Toronto, Canada
Presence of cellular components in vaccines
Valentina A Dіvocha
1
and
Yaroslav Basarab
2
1
Ukrainian Research Institute of Transport Medicine, Ukraine
2
Ukrainian State Medical Dental Academy, Ukraine
N
ow preventive maintenance of a flu by means of
vaccination is conventional and is supported by experts
from all over world. Aim of the present study is to check
presence of trypsin-like proteinase and its inhibitor in
antiflu and other vaccines and in immunobiological blood
preparations of domestic and foreign manufacture. In
work following commercial preparations have been used:”
Interferon leukocytic human”,” the Immunoglobulin of human
placental, donor 10 %, a gonococcal vaccine a herpetic
vaccine (Odessa), vaccines for preventive maintenance
of a flu, a season 2002/2003 -”Influvac” which consists of
hemagglutinins and a neuraminidase of a virus of a flu,
strains: А/Moscow/10/99 (H3N2), А/New Caledonia/20/99
(H/N), B/Hong Kong/330/2001, “Fluarix” which consists
of hemagglutinins of strains (H1N1) A/New Caledonia
(H3N2), А/Panama and В/Shandont 17/97 and “Vaxigrip”
which consists of three strains of a flu virus, a vaccine for
preventive maintenance of a hepatitis A - “Avaxim”, a blood
preparation received from a heparin (the antifactor of Ha)
- “Fraxiparine”, a preparation from a blood of calfs for a
hemodialysis - “Solcoseryl”. Preparations were investigated
before the termination of a period of validity. Work is devoted
to study presence of components of a cell-owner and its
inhibitor in vaccines and blood preparations and to define
presence trypsin-like proteinase and its inhibitor in vaccines
and blood preparations. It is revealed that anti influenza
vaccines (influvac, vaxigrip, fluarix), herpetic and tularemic
vaccines contained an inhibitor of trypsin-like proteinase in
considerable quantity. Commercial preparations froma human
donor blood (an immunoglobulin, interferon, fraxiparine
and solcoseryl) contained as trypsin-like proteinase, and its
inhibitor. The immunoglobulin contained in 4, 0 times more
inhibitor, than interferon. Hence, the modern vaccines applied
to prophilaxis and treatment, are insufficiently cleared.
Presence of cellular components (enzymes and inhibitors)
could lead to allergization and follow complication which is
not very known.
Speaker Biography
Valentina A Divocha is graduated from I I Mechnikov Odessa State University, Faculty
of Biology (Department of Virology) in 1967. In 1973, she continued her Postgraduate
study at Odessa Institute of Virology and Epidemiology (specialty virology). In 1974,
she was awarded with her candidate degree thesis entitled interaction of coxsackie B
viruses with sensitive cell cultures and their antigenic relationships. In 2009, she was
awarded her Doctoral degree with the thesis entitled biological basis antiproteinase
therapy of influenza. Under her leadership she has guided a doctoral and two
master’s theses. Her scientific experience is of 35 years. She has more than 190
scientific publications, three monographs, textbook
Virology
(2012), 10 patents, three
innovations. She is currently working as the Head of the Laboratory of Experimental
and Clinical Pathology for Ukrainian Research Institute of Transport Medicine, is the
Supervisor of the nine research programs in virology and biochemistry.
e:
divocha09@ukr.net