euro-obesity-euro-vaccines-2018-posters

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J u n e 2 8 - 2 9 , 2 0 1 8 | A m s t e r d a m , N e t h e r l a n d s

Joint Event on

OBESITY AND WEIGHT MANAGEMENT

VACCINES AND IMMUNOLOGY

International Conference on

Asian Journal of Biomedical and Pharmaceutical Sciences

Volume 8

ISSN:

2249-622X

IMMUNOLOGICAL ASPECTS OF SUBLINGUAL AND

SUBCUTANEOUS ALLERGEN-SPECIFIC IMMUNOTHERAPY

Nerin Nadir Bahceciler Onder

Near East University, Cyprus

lthough, allergen specific sublingual (SL) and subcutaneous immunotherapy (SCIT) have been demonstrated to be clinically

efficient with similar immunological responses, head to head studies comparing those two modes of allergen administration

in terms of onset of clinical improvement along with simultaneous immunological responses and underlying mechanisms of

preventive effect is scarce. Compared to SLIT, SCIT provides a rapid onset of clinical improvement by eliciting a simultaneous

surge in production of Th1 and Treg cytokines and blocking antibodies. Similar immunological and clinical responses are evoked

quite later, with no effect on IgG4 levels during SLIT. Increases in TGF-beta secretion due to non-relevant allegens during SLIT may

explain the preventive effect on new sensitizations. SLIT and SCIT are both clinically efficient in the treatment of respiratory allergic

diseases with slight differences in the early phase in terms of onset of clinical efficacy and simultaneous immunological responses.

Both SLIT and SCIT induce similar T cell responses with different dynamics, but specific IgG4 blocking antibody responses are more

prevelant following SCIT. Further studies addressing the efficacy and immunological responses multiallergen IT in polysensitized

patients are warranted. Updated scientific data on immunological and clinical tolerance of SLIT vs. SCIT will be presented.

Asian J Biomed Pharmaceut Sci 2018, Volume 8 | DOI: 10.4066/2249-622X-C1-003