euro-gastroenterology-clinical-pharmacy-2019-accepted

Euro Gastroenterology 2019 & Clinical Pharmacy 2019

Archives of General Internal Medicine | ISSN: 2591-7951 | Volume 3

Page 55

Note:

March 25-26, 2019 | Amsterdam, Netherlands

GASTROENTEROLOGY AND HEPATOLOGY

International Conference on

CLINICAL PHARMACY & PHARMACY PRACTICE

World Congress on

Joint Event on

OF EXCELLENCE

IN INTERNATIONAL

MEETINGS

YEARS

MSI CANCER: FROM GENOMICS TO PERSONALIZED MEDICINE

Duval Alex

Saint Antoine Research Center, France

he human tumor phenotype referred to as MSI (Microsatellite Instability) arises because of defects in the

DNA mismatch repair (MMR) system. MSI was first observed in inherited tumors associated with Lynch

syndrome and later in approximately 10-15% of sporadic colon, gastric and endometrial cancers, as well as

in a small proportion (1-5%) of many other primary tumour types. The normal function of the MMR system is

to recognize and repair the errors that arise during DNA replication, as well as to repair some forms of DNA

damage. It is now well established that MMR deficiency is not in itself a direct transforming event and that MSI

tumors develop through a distinctive molecular pathway characterized by the genetic instability of numerous

microsatellite repeated sequences throughout the genome. These mutations accumulate in tumor cells to-

gether with other somatic alterations at non-repetitive DNA sequences. The overall aim of our research team

is to decipher the important genomic and pathophysiological aspects of MSI carcinogenesis and to benefit

from our findings to open perspectives for the precision medicine of MSI cancer. The overall aim of my talk

will be to describe some important pathophysiological aspects of MSI carcinogenesis, reporting how the in-

vestigation of mechanisms underlying MSI-driven tumor development has also led us to identify diagnostic

tools, risk factors, prognostic biomarkers, and new targets for personalized treatments of patients suffering

from MSI tumors.

Arch Gen Intern Med 2019, Volume 3 | DOI: 10.4066/2591-7951-C1-024