dermatology-2019-posters

2 / 3

Note:
Page 35
April 11-12, 2019 | Barcelona, Spain
OF EXCELLENCE
IN INTERNATIONAL
MEETINGS
YEARS
Dermatology 2019 Research in Clinical Dermatology | Volume 2
3rd WORLD DERMATOLOGY
AND COSMETOLOGY CONGRESS
GENETIC STUDIES ON PSORIASIS: ROLE OF METHYLENETETRAHYDROFOLATE
REDUCTASE (MTHFR) C677T GENE POLYMORPHISM
Abdulrahman Al-Asmari
Scientific Research Center, KSA
Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting approximately 120-180 million
people worldwide. The pathogenesis of psoriasis is very complex and several different etiological hypothe-
ses including those of the genetic, environmental and immunological factors have been suggested to explain
its pathogenesis. Methylenetetrahydrofolate reductase (MTHFR) has been linked with the etiopathogenesis of
psoriasis with inconsistent results. The aim of this study was to determine if the MTHFR (C677T) polymorphism
confers susceptibility to psoriasis in Saudi population. We evaluated MTHFR C677T polymorphism in 106 Saudi
psoriasis vulgaris patients and 280 matched healthy controls. MTHFR C677T genotyping was performed by
PCR–RFLP technique. Allele T and genotypes CT, TT were found to be increased while allele C and genotype
CC significantly decreased in psoriasis patients than controls (p <0.001). This study indicates that the T-allele
and T-containing genotypes (TT, CT) of MTHFR C677T polymorphism are significantly associated with psoriasis
while C-allele and CC genotype may be protective for it. BMI, fasting glucose, triglycerides, total cholesterol,
low-density lipoprotein and C-reactive protein, known markers for cardiovascular diseases were found to be
significantly elevated in the patient group as compared to the controls. It is concluded that the MTHFR C677T
polymorphism increases psoriasis risk in Saudi patients and ultimately may lead to cardiovascular and other
systemic disorders.
Abdulrahman Al-Asmari, Res Clin Dermatol 2019, Volume 2
Abdulrahman Al-Asmari has completed his PhD in 1996 from University of London, London, UK. Earlier he received MPhil (biochem-
istry) on his work entitled “Proteomic studies of snake venoms and their biological activity” from London, UK. He is the director of
Scientific Research Center, MSD Riyadh Saudi Arabia. He has over 100 publications that have been cited several times, and has been
serving as an editorial board member of various journals.
BIOGRAPHY