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academies
July 23-25, 2018 | Moscow, Russia
12
th
World Cancer Congress
Journal of Medical Oncology and Therapeutics | Volume: 3
H
ypoxia as one characteristic hallmark of solid tumors has
been demonstrated to involve in cancer metastasis and
progression, induce severe resistance to oxygen-dependent
therapies and hamper the transportation of theranostic
agents. To address these issues, an oxygen self-produced
sonodynamic therapy (SDT) nanoplatform involving modified
fluorocarbon (FC) chains-mediated oxygen delivery protocol
has been established to realize highly-efficient SDT against
hypoxic pancreatic cancer. In this nanoplatform, mesopores
and FC chains of FC chainsfunctionalized hollow mesoporous
organosilica nanoparticles (FHMONs) carriers can provide
sufficient storage capacity and binding sites for sonosensitizers
(IR780) andoxygen, respectively. Invitroand invivoexperiments
demonstrate the nanoplatform involving this distinctive
oxygen delivery protocol indeed breaks the hypoxia-specific
transportation barriers, supplies sufficient oxygen to hypoxic
PANC-1 cells especially upon exposure to ultrasound irradiation
and relieves hypoxia. Consequently, hypoxia-induced resistance
to SDT is inhibited and sufficient highly reactive oxygen species
(ROS) are produced to kill PANC-1 cells and shrinkage hypoxic
PANC-1 pancreatic cancer. This distinctive FC chains-mediated
oxygen delivery method provides an avenue to hypoxia
oxygenation, and holds great potential in mitigating hypoxia-
induced resistance to those oxygen-depleted therapies, e.g.,
photodynamic therapy (PDT), radiotherapy, chemotherapy, etc.
Speaker Biography
Yongxiang Zhao is the innovative leading talent of National “Ten Thousand Talent
Programme”, the Director of the National Center for International Research of
Biological Targeting Diagnosis and Therapy, the moderator of the BIT’s 5
th
World Gene
Convention Keynote Forum, Nobel Laureate Forum, the national talented person of
“New Centuary National Hundred, Thousand and Ten Thousand Talent Project”. The
leader of National Innovative Talent Promotion Program Innovation Team of National
Key Fields, the leader of National Innovation Team for the Changjiang Scholars Project,
the expert of National “Ten Thousand Talent Programme” and “Changjiang Scholars
Programme”, the expert of National Natural Science Foundation of subject review
group, the standing Director of Chinese Immunological Society, the member of Chinese
Medical Association Professional Committee of Clinical Precision Medicine, the expert
of National Science and Technology Award Assessment, the member of Chinese
medical science and Technology Award Evaluation Committee, the member of Gene
Therapy Branch of Chinese Medical Association. The reviewers and editorial board
members of multiple SCI journals such as Nature. He has taken charge of 14 national
science and technology major projects and 16 provincial and ministerial projects.
e:
yongxiang_zhao@126.comYongxiang Zhao
Guangxi Medical University, China
Oxygen self-produced nanoplatform for relieving hypoxia and breaking resistance to
sonodynamic treatment of Pancreatic Cancer