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Asian Journal of Biomedical and Pharmaceutical Sciences | Volume 8
May 14-15, 2018 | Montreal, Canada
Global Summit on
Biopharma & Biotherapeutics
T
he identification and validation of drug targets are crucial
in biomedical research and many studies have been
conducted on analyzing drug target features for getting a
better understanding on principles of their mechanisms.
But most of them are based on either strong biological
hypotheses or the chemical and physical properties of those
targets separately. In this paper, we investigated three main
ways to understand the functional biomolecules based on the
topological features of drug targets. There are no significant
differences between targets and common proteins in the
protein-protein interactions network, indicating the drug
targets are neither hub proteins which are dominant nor
the bridge proteins. According to some special topological
structures of the drug targets, there are significant
differences between known targets and other proteins.
Furthermore, the drug targets mainly belong to three typical
communities based on their modularity. These topological
features are helpful to understand how the drug targets
work in the PPI network. Particularly, it is an alternative way
to predict potential targets or extract nontargets to test a
new drug target efficiently and economically. By this way, a
drug target’s homologue set containing 102 potential target
proteins is predicted in the paper.
Speaker Biography
Ragaee Shokralla has completed his Pharm D degree at the age of 26 years from
Alexandria University, Egypt. He is a clinical pharmacist at Ministry of Health - Kuwait.
e:
Ragaee.shokralla@yahoo.comDrug target protein-protein interaction networks: A systematic perspective
Ragaee Shokralla
Ministry of Health, Kuwait