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allied
academies
Nov12-13, 2018 | Paris, France
Central Nervous System & Therapeutics
International Conference on
Journal of Neurology and Neurorehabilitation Research | Volume 3
Imaging of Alzheimer’s misfolded proteins in the retina
Umur Kayabasi
1
and
John Rose Sr
2
1
Bahcesehir University, Turkey
2
John Rose Eye Center, UK
Background:
Recent research suggests that Tau is the culprit
lesion along with neuroinflammation in the etiology of
Alzheimer’ s Disease ( AD ). Retina is the extention of the brain
and is the most easily approachable part of the central nervous
system. Detection of the pathological protein accumulations
may be possible by using spectral domain optical coherescent
tomography ( SD-OCT ) and fundus autofluorescein ( FAF ). There
is evidence showing that retinal plaques start accumulating
even earlier than the ones in the brain. Most recent Tau protein
images in the brain consist of normal or reverse C-shaped
paired hellical filaments.
Methods:
20 patients with PET proven AD were examined by
SD-OCT and FAF. Mean age was 72. Hypo or hyperfluorescent
retinal lesions were scanned by SD-OCT and C shaped paired
hellical filaments were investigated in a masked fashion. The
researchers agreed on the shape of the lesions. Both C-shaped
( normal or reverse ) filaments and thinner fibrillary structures
were taken into consideration.
Results:
In all the patients, paired hellical filaments that exactly
corresponded with the histopathologic and cryo-EM images
of Tau in terms of shape and dimension were detected along
with thin fibrils and lesions similar to amyloid beta. The
number of the retinal filaments and other abnormal proteins
was in concordance with the severity of the disease process.
The advanced retinal filaments had normal or reverse paired C
shapes and thin fibrils had the shape of histopathologic images
seen in early developmental stages of the disease.
Conclusions:
Retinal images of Tau were disclosed for the first
time in live AD patients. Retinal neuroimaging is a trustable
biomarker and tool for monitoring the disease.
e:
kayabasi@yahoo.com