Commentary - Journal of Parasitic Diseases: Diagnosis and Therapy (2021) Volume 6, Issue 1
SARS-CoV-2 Infection increases its effect in smoking.
Smoking is thought to increase the risk of cardiovascular and respiratory illnesses, including infections, so susceptibility to serious illness from COVID-19 is expected to be linked to it. This is particularly valid now that a new coronavirus strain, the extreme acute respiratory syndrome coronavirus (SARS-CoV-2), has arisen and sparked the latest pandemic, coronavirus disease 2019 (COVID-19). While the effects of smoking on COVID-19 are less well known and controversial, we agree there is a connection between the two. SARS-CoV-2 uses the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) primary entry genes to infect cells and cause a cytokine storm, which has been shown to increase the severity of the COVID-19 clinical path. Nonetheless, the effect of smoking on the expression of the ACE-2 and TMPRSS2 receptors is perplexing. As a result, further research is needed to understand the connection between smoking and COVID-19, as well as to explore the advancement of new treatments that can reduce the morbidity and mortality caused by this infectious disease.