Aim: Intrauteine treatment of fetal growth restriction (FGR).
Method: The mechanism to decrease villous transfer of nutrition followed by fetal asphyxia. Fetal was studied, and detected fibrin deposit in the placenta by the high gray level histogram width (GLHW) tissue characterization higher than normal placenta, then the fibrin deposit was soluted by maternal heparin injection in 17-31 gestational weeks.
Results: High GLHW reduced and estimated fetal weight increased to normal levels after heparin treatment. Normal neonate without asphyxia was born by caesarean delivery at 38 weeks.
Discussion: Also a fetus died after placental infarction caused by preeclampsia, which will be treated by the perioheral arterial anti-sympathicotonic therapy. Genetic FGR may receive genetic therapy in the future.
Conclusion: Heparin treatment was effective to treat FGR caused by placental fibrin deposit. Other FGRs may be treated by their causative therapy.