Biomedical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-7360-538437

Research Article - Biomedical Research (2017) Volume 28, Issue 10

To evaluate the efficacy of GLP-1 analogues on the blood sugar levels, insulin resistance, islet β-cell function and pre-diabetes of the children

Background: To evaluate the clinical efficacy of Glucagon-Like Peptide-1 (GLP-1) analogues on the blood sugar levels, insulin resistance, islet β-cell function and pre-diabetes of the children.

Methods: Prospective and randomized controlled clinical trial was done on 82 cases of newly diagnosed pre-diabetes in children. First group was comprised of 41 subjects of lifestyle intervention group i.e. control group and the second group were comprised of 41 subject of lifestyle intervention+GLP-1 analogs liraglutide group i.e. observation group. Interventions were done lasted for 3 months. Review of intervention was done at 1 month and at after the 3 months. We carried out the medical examinations at the time when the patient had been diagnosed with prediabetes and after the intervention of 3 months. The medical test examinations includes the Fasting Blood Glucose (FPG), 2 h Postprandial Blood Glucose (2hPG), detection of glycated haemoglobin (HbA1C), Total Cholesterol (TC), Triglyceride (TG), Low Density Lipoprotein Cholesterol (LDL-C), High Density Lipoprotein Cholesterol (HDL-C), BMI, insulin resistance and the islet cell functions.

Results: After the 1 month of intervention, the observation group showed a better control on FPG and 2hPG compared with the control group (P<0.05). The levels of HbA1C, TC, TG, LDL-C, HDL-C, and BMI of the observation group were statistically better controlled, when compared with the control group after the intervention of 3 months. The insulin resistance index of the observation group was significantly decreased than that of the control group (P<0.05) and the islet function index of the β cell of the observation group showed statistically higher values than that of the control group (P<0.05).

Conclusions: GLP-1 analogs could be a better controller of blood sugar levels, effectively improve lipid profile, body mass, insulin resistance and islet β-cell function. Furthermore, GLP-1 analogs open up a new way to intervene pre-diabetes in children.

Author(s): Ruifeng Li, Gaofeng Wang

Abstract Full Text PDF

Get the App